朱红艳
师资介绍
姓名：朱红艳
性别：女
民族：汉族
出生年月：1978.06.23
职称：教授
学历：博士
职务：药物制剂系党支部书记
研究方向：1.核酸药物递释系统；2.仿生药物递送系统。
主持或参加科研项目（课题）
1. 江苏省自然科学基金面上项目，BK20201443，靶向调控肿瘤转移前微环境的工程化“外泌体影”仿生递释系统研究，2020/7-2023/6，10万元，在研，主持 ；
2. 国家自然科学基金青年基金项目，81202467，胞内触发释药的仿生型siRNA自组装胶束纳米复合物的构建、抗肿瘤转移作用及细胞内药物动力学研究，2013/1-2015/12，23万元，已结题，主持 ；
3. 江苏省青年科学基金项目，BK2012232，靶向肿瘤血管生成的仿生型小核酸药物递释系统研究，2012/7-2015/7，20万元，已结题，主持 ；
4. 江苏省教育厅高校自然科学研究面上项目，11KJB350004，谷胱甘肽触发释放的智能型siRNA复合载体（穿膜肽Tat-壳聚糖-量子点）的构建及其抗肿瘤活性研究，2011/01-2014/12，3万元，已结题，主持 ；
5. 江苏省高校自然科学研究指导性项目，06KJD310150，南瓜多糖对链脲菌素诱导的胰岛损伤的保护作用及机制研究，2007/01-2008/12，1万元，已结题，主持。
6. 南通市课题，Exosome@CBSA 仿生 siRNA 递送系统的构建及其抗乳腺癌术后转移作用研究，2018.07-2020.06，项目编号：JC2018024，5万元。
代表性研究成果和学术奖励情况
第一作者和通讯作者论文，专利
(2) Haiqin Huang, Lanlan Shao, Yan Chen, Weili Han, Yao Zhou, Tianqing Liu, Jinhua Gu,* and Hongyan Zhu*. Sequential Dual Delivery System Based on siCOX-2-Loaded Gold Nanostar and Thermal-Sensitive Liposomes Overcome Hypoxia Mediated Multidrug Resistance in Tumors. Mol. Pharmaceutics. 2022, 19(7):2390-2405.
(3) Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Hongyun Li, Hongyan Zhu* and Tianqing Liu*. Docetaxel-loaded M1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer. Journal of Nanobiotechnology. 2022, 20:359.
(4) Haiqin Huang, Lanlan Shao, Yan Chen, Lan Tang, Tianqing Liu, Junxu Li, and Hongyan Zhu*. Synergistic strategy with hyperthermia therapy based immunotherapy and engineered exosomes liposomes targeted chemotherapy prevents tumor recurrence and metastasis in advanced breast cancer. Bioeng Transl Med. 2021, 7(2):e10284.
(5) Shengyu Zhang, Ye Gan, Lanlan Shao, Tianqing Liu, Danyi Wei, Yanyan Yu,* Hongwei Guo,* and Hongyan Zhu*. Virus Mimetic Shell-Sheddable Chitosan Micelles for siVEGF Delivery and FRET-Traceable Acid-Triggered Release. ACS Appl. Mater. Interfaces. 2020, 12, 53598−53614.（IF=9.229）
(6) Liuwan Zhao, Chunyan Gu, Ye Gan, Lanlan Shao, Hongwei Chen, Hongyan Zhu*. Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis. J Control Release. 2020, 318, 1-15.（IF=9.776）
(7) Hongyan Zhu,Weili Han, Ye Gan, Qiaofeng Li, Xiaolan Li, Lanlan Shao, Dan Zhu* and Hongwei Guo*. Combined Modality Therapy Based on Hybrid Gold Nanostars Coated with Temperature Sensitive Liposomes to Overcome Paclitaxel-Resistance in Hepatic Carcinoma. Pharmaceutics 2019, 11(12), 683（IF=6.321）
(8) Yanyan Yu, Min Zhou, Wei Zhang, Lei Huang, Dandan Miao, Hongyan Zhu*, Gaoxing Su*. Rattle-Type Gold Nanorods/Porous-SiO2 Nanocomposites as Near-Infrared Light-Activated Drug Delivery Systems for Cancer Combined Chemo-Photothermal Therapy. Mol. Pharmaceutics. 2019,16(5) 1929-1938（IF=4.939）
(9) Su G, Miao D, Yu Y, Zhou M, Jiao P, Cao X, Yan B, Zhu H*. Mesoporous silica-coated gold nanostars with drug payload for combined chemo-photothermal cancer therapy. J Drug Target. 2019 Feb; 27(2):201-210. （IF=5.121）
(10) Shengyu Zhang, Yanjun Liu, Ye Gan, Nanqing Qiu, Yueqing Gu, Hongyan Zhu*. Conjugates of TAT and folate with DOX-loaded chitosan micelles offer effective intracellular delivery ability. Pharm Dev Technol. 2019, 24(2):253-261.（IF=3.133）
(11) Shengyu Zhang, Liuwan Zhao, Nanqin Qiu, Yanjun Liu, Bohui Xu, Hongyan Zhu*, On the hypoxic tumor targeting ability of two chitosan micelles loaded with oil-soluble CdSe quantum dots. Pharm Dev Technol. 2018, 23(1):87-95.（IF=3.133）
(12) Hongyan Zhu*, Wanwan Liu, Ziting Cheng, Ke Yao, Yu Yang, Bohui Xu and Gaoxing Su*, Targeted Delivery of siRNA with pH-Responsive Hybrid Gold Nanostars for Cancer Treatment. Int J Mol Sci. 2017, 18(10):2029.（IF=5.923）
(13) Fei Liu, Yuan Sun, Chen Kang, Hongyan Zhu*. Pegylated drug delivery systems: from design to biomedical applications. Nano Life. 2016, 6(3, 4):1642002 (1-11).
(14) Bohui Xu, Yubin Wang, Hongyan Zhu*. Mini-tablet combination for sustained release of clonidine hydrochloride and hydrochlorothiazide: Preparation and pharmacokinetics in beagle dogs. Pharmazie. 2016 71(2):76-83. （IF=1.267）
(15) Hongyan Zhu, Shengyu Zhang, Yongling, Guoliang Meng, Yu Yang, Wei Zhang*. pH-responsive hybrid quantum dots for targeting hypoxic tumor siRNA delivery. J Control Release. 2015, 220(Pt A):529-544. （IF=9.776）
(16) Hongyan Zhu, Guangtong Chen, Guoliang Meng Jiliang Xu*. Characterization of pumpkin polysaccharides and protective effects on streptozotocin-damaged islet cells. Chin J Nat Med. 2015, 13(3):199-207. （IF=3.000）
(17) Hongyan Zhu, JingPing Zhu, AiMei Xie, Yong Lin, BeiBei Zhang, YiFei Wang, Wei Zhang*.Visible quantum-dot-based targeted siRNA delivery for HIF-1α gene silencing. J. Drug Del. Sci. Tech. 2014, 24 (5): 445-451.（IF=3.981）
(18) Hongyan Zhu, Jie Cao, Sisi Cui, Zhiyu Qian, Yueqing Gu*. Enhanced tumor targeting and antitumor efficacy via hydroxycamptothecin-encapsulated folate-modified N-succinyl-N′-octyl chitosan micelles. J Pharm Sci. 2013, 102 (4):1318-1332. （IF=3.534）
(19) Hongyan Zhu, Fei Liu, Jing Guo, Jianpeng Xue, Zhiyu Qian, Yueqing Gu*. Folate-modified chitosan micelles with enhanced tumor targeting evaluated by near infrared imaging system. Carbohydrate Polymers. 2011, 86(3):1118-1129. （IF=9.381）
(20) Jie Cao#, Hongyan Zhu#, Dawei Deng, Bing Xue, Liping Tang, Didel Mahounga, Zhiyu Qian, Yueqing Gu*, In vivo NIR imaging with PbS quantum dots entrapped in biodegradable micelles. Journal of Biomedical Materials Research Part A. 2012: 100A: 958-968. （IF=4.396）
(21) 程紫婷，姚珂，刘婉婉，许伯慧，朱红艳*, 紫杉醇温敏脂质体与siRNA金纳米星载药系统的构建与表征. 中国药科大学学报. 2017, 48(4):444-45.
(22) 朱红艳, 朱景平, 谢爱梅, 袁静, 花烨, 张伟*. 肿瘤靶向高分子碲化镉量子点复合纳米粒的制备及其表征. 药学学报. 2014, 49 (10): 1457 -1465.
(23) 刘婉婉，张胜喻，杨彧，朱红艳*. 具有肿瘤靶向及穿膜效应的壳聚糖胶束的制备. 中国药科大学学报. 2015, 46(5): 561-567.
(24) 周瑶，曹欣雨，周佳敏，朱红艳*. 口服维生素C脂质体的制备及其稳定性研究. 南通大学学报（医学版）. 2020, 40(5): 1-3.
(25) 发明专利：朱红艳, 许伯慧, 陈忠平. 一种仿生siRNA胶束纳米复合物及应用. 专利号：ZL 2015 1 0189351.6，授权日：2018.07.24.
(26) 朱红艳，赵刘碗，韩伟莉. 复合siRNA纳米载体及其制备方法和应用. 专利号：201810990330.8。
(27) 已经转让的专利：朱红艳, 谢爱梅, 杨池, 张贝贝, 王逸飞. 一种基于量子点的多功能纳米siRNA载体系统的制备及应用. 专利号：ZL 2014 1 0087972.9，转让时间：2020年，转让经费：4万元。
(28) 朱红艳,赵刘碗, 韩伟莉. 光热材料和外泌体介导的化疗药组成的药物及其用途. 申请号：2019101129258, 实审发文号：2019042800173150.