江波
师资介绍
江波，男，汉族，1986-11-02，教授，博士，博导；江苏省333人才工程第三层次，并担任Frontiers in Pharmacology期刊杂志副编辑。
研究方向：神经精神药理学
基金项目：
1. FBXL19与USP14双向调节室旁核CBP稳定在慢性应激致HPA轴亢奋进程中的效应研究。（国家自然科学基金面上项目；82371519；南通大学；2024/01-2027/12：47万；正在进行）
2. 室旁核QRFP-GPR103系统调控HPA轴亢奋在抑郁症发病机理中的作用研究。（国家自然科学基金面上项目；82071519；南通大学；2021/01-2024/12：55万；正在进行）
3. 下丘脑SIK1-CRTC1通路在抑郁症病理过程中的作用及机制研究。（国家自然科学基金面上项目；81873795；南通大学；2019/01-2022/12：56万；已结题）
4. 海马miR-206-3p介导参与抑郁症的相关研究。（江苏省高校自然科学基金面上项目；18KJB310013；南通大学；2018/09-2020/08：3万；已结题）
5. 海马miR-206-3p，一种新型抗抑郁靶点及相关药物的研究。（南通市科技计划民生科技面上项目；MS12018076；南通大学；2018/07-2020/06：10万；已结题）
6. 海马BMP4-Smad4信号通路在慢性应激诱导抑郁症中的作用及机制研究。（江苏省自然科学基金面上项目；BK20161284；南通大学；2016/07-2019/06；10万；已结题）
7. 过氧化物酶体增殖物活化受体α（PPARα）在抑郁症病理生理过程中的作用及其机制研究。（国家自然科学基金青年基金；81401116；南通大学；2015/01-2017/12；23万；已结题）
8. 盐诱导激酶2（SIK2）在抑郁症病理过程中的作用研究。（江苏省高校自然科学基金面上项目；14KJB310013；南通大学；2014/07-2016/12；5万；已结题）
科研成果：
(1) Huang J, Fan H, Chen YM, Wang CN, Guan W, Li WY, Shi TS, Chen WJ, Zhu BL, Liu JF, Jiang B. The salt-inducible kinases inhibitor HG-9-91-01 exhibits antidepressant-like actions in mice exposed to chronic unpredictable mild stress. Neuropharmacology. 2023, 227:109437.
(2) Wang Y, Liu L, Gu JH, Wang CN, Guan W, Liu Y, Tang WQ, Ji CH, Chen YM, Huang J, Li WY, Shi TS, Chen WJ, Zhu BL, Jiang B. Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis. Mol Psychiatry. 2022 Nov 25, [Online ahead of print], doi: 10.1038/s41380-022-01881-4.
(3) Wu ZH, Fan H, Gao SY, Jin YF, Cheng Chen, Jiang B, Shen J. Antidepressant-like activity of oroxylin A in mice models of depression: A behavioral and neurobiological characterization. Front Pharmacol. 2022, 13:921553.
(4) Tang WQ, Liu Y, Ji CH, Gu JH, Chen YM, Huang J, Guan W, Xu DW, Jiang B. Virus-mediated decrease of LKB1 activity in the mPFC diminishes stress-induced depressive-like behaviors in mice. Biochem Pharmacol. 2022, 197:114885.
(5) Ji CH, Gu JH, Liu Y, Tang WQ, Guan W, Huang J, Chen YM, Xu DW, Jiang B. Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis. Biochem Pharmacol. 2022, 195:114836.
(6) Chen YM, Fan H, Huang J, Shi TS, Li WY, Wang CN, Jiang B, Liu JF. Hippocampal F3/Contactin plays a role in chronic stress-induced depressive-like effects and the antidepressant actions of vortioxetine in mice. Biochem Pharmacol. 2022, 202:115097.
(7) Guan W, Xu DW, Ji CH, Wang CN, Liu Y, Tang WQ, Gu JH, Chen YM, Huang J, Liu JF, Jiang B. Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF. Pharmacol Res. 2021, 174:105932.
(8) Wang Y, Gu JH, Liu L, Liu Y, Tang WQ, Ji CH, Guan W, Zhao XY, Sun YF, Xu DW, Jiang B. Hippocampal PPARα Plays a Role in the Pharmacological Mechanism of Vortioxetine, a Multimodal-Acting Antidepressant. Front Pharmacol. 2021, 12:673221.
(9) Guan W, Gu JH, Ji CH, Liu Y, Tang WQ, Wang Y, Jiang B. Xanthoceraside administration produces significant antidepressant effects in mice through activation of the hippocampal BDNF signaling pathway. Neurosci Lett. 2021, 757:135994.
(10) Liu Y, Tang W, Ji C, Gu J, Chen Y, Huang J, Zhao X, Sun Y, Wang C, Guan W, Liu J, Jiang B.The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway. Front Pharmacol. 2021, 11:624429.
(11) Zhao J, Zhang Y, Liu Y, Tang WQ, Ji CH, Gu JH, Jiang B.Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression.Neurosci Lett. 2021, 742:135535.
(12) Liu L, Ji CH, Wang Y, Zhao J, Liu Y, Tang WQ, Gu JH, Jiang B.Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization.Behav Brain Res. 2021, 399:113038.
(13) Wang JL, Wang Y, Gao TT, Liu L, Wang YJ, Guan W, Chen TT, Zhao J, Zhang Y, Jiang B.Venlafaxine protects against chronic stress-related behaviors in mice by activating the mTORC1 signaling cascade. J Affect Disord. 2020, 276:525-536.
(14) Gao TT, Wang Y, Liu L, Wang JL, Wang YJ, Guan W, Chen TT, Zhao J, Jiang B.LIMK1/2 in the mPFC Plays a Role in Chronic Stress-Induced Depressive-Like Effects in Mice.Int J Neuropsychopharmacol. 2020, 23(12):821-836.
(15) Wang YJ, Liu L, Wang Y, Wang JL, Gao TT, Wang H, Chen TT, Guan W, Jiang B.Imipramine exerts antidepressant-like effects in chronic stress models of depression by promoting CRTC1 expression in the mPFC.Brain Res Bull. 2020, 164:257-268.
(16) Wang CN, Gong SN, Guan W, Wang JL, Gao TT, Wang Y, Sun F, Jiang B. Hippocampal overexpression of chordin protects against the chronic social defeat stress-induced depressive-like effects in mice. Brain Res Bull. 2020, 158:31-39.
(17) Chen C, Shen JH, Xu H, Chen P, Chen F, Guan YX, Jiang B, Wu ZH. Hippocampal PPARα is involved in the antidepressant-like effects of venlafaxine in mice. Brain Res Bull. 2019, 153:171-180.
(18) Zhang JJ, Gao TT, Wang Y, Wang JL, Guan W, Wang YJ, Wang CN, Liu JF, Jiang B. Andrographolide Exerts Significant Antidepressant-Like Effects Involving the Hippocampal BDNF System in Mice. Int J Neuropsychopharmacol. 2019, 22(9): 585-600.
(19) Jiang B, Wang H, Wang JL, Wang YJ, Zhu Q, Wang CN, Song L, Gao TT, Wang Y, Meng GL, Wu F, Ling Y, Zhang W, Li JX. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway. Biol Psychiatry. 2019, 85(8):650-666.
(20) Song L, Wang H, Wang YJ, Wang JL, Zhu Q, Wu F, Zhang W, Jiang B. Hippocampal PPARα is a novel therapeutic target for depression and mediates the antidepressant actions of fluoxetine in mice. Br J Pharmacol. 2018, 175(14):2968- 2987.
(21) Ni YF, Wang H, Gu QY, Wang FY, Wang YJ, Wang JL, Jiang B. Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system. J Psychopharmacol. 2018, 32(4):469-481.
(22) Xu D, Sun Y, Wang C, Wang H, Wang Y, Zhao W, Bao G, Wang F, Cui Z, Jiang B. Hippocampal mTOR signaling is required for the antidepressant effects of paroxetine. Neuropharmacology. 2018, 128:181-195.
(23) Ren Y, Wang JL, Zhang X, Wang H, Ye Y, Song L, Wang YJ, Tu MJ, Wang WW, Yang L, Jiang B. Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression. Brain Res Bull. 2017, 134:211-219.
(24) Wang H, Zhao Y, Wang YJ, Song L, Wang JL, Huang C, Zhang W, Jiang B. Antidepressant-like effects of tetrahydroxystilbene glucoside in mice: Involvement of BDNF signaling cascade in the hippocampus. CNS Neurosci Ther. 2017, 23(7):627-636.
(25) Wang CN, Wang YJ, Wang H, Song L, Chen Y, Wang JL, Ye Y, Jiang B. The Anti-dementia Effects of Donepezil Involve miR-206-3p in the Hippocampus and Cortex. Biol Pharm Bull. 2017, 40(4):465-472.
(26) Jiang B, Wang YJ, Wang H, Song L, Huang C, Zhu Q, Wu F, Zhang W. Antidepressant-like effects of fenofibrate in mice via the hippocampal BDNF signaling pathway. Br J Pharmacol. 2017, 174(2):177-194.
(27) Jiang B, Song L, Wang CN, Zhang W, Huang C, Tong LJ. Antidepressant-Like Effects of GM1 Ganglioside Involving the BDNF Signaling Cascade in Mice. Int J Neuropsychopharmacol. 2016, 19(9).
(28) Jiang B, Huang C, Chen XF, Tong LJ, Zhang W. Tetramethylpyrazine Produces Antidepressant-Like Effects in Mice Through Promotion of BDNF Signaling Pathway. Int J Neuropsychopharmcol. 2015, 18(8).
(29) Jiang B, Huang C, Zhu Q, Tong LJ, Zhang W. WY14643 produces anti-depressant-like effects in mice via the BDNF signaling pathway. Psychopharmacology. 2015, 232(9):1629-1642.
(30) Jiang B, Wang F, Yang S, Fang P, Deng ZF, Xiao JL, Hu ZL, Chen JG. SKF83959 produces antidepressant effects in a chronic social defeat stress model of depression through BDNF-TrkB pathway. Int J Neuropsychopharmacol. 2014, 18(6).
(31) Jiang B, Wang W, Wang F, Hu ZL, Xiao JL, Yang S, Zhang J, Peng XZ, Wang JH, Chen JG. The stability of NR2B in the nucleus accumbens controls behavioral and synaptic adaptations to chronic stress. Biol Psychiatry. 2013, 74(2):145-155.
(32) Jiang B, Xiong Z, Yang J, Wang W, Wang Y, Hu ZL, Wang F, Chen JG. Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus. Br J Pharmacol. 2012, 166(6):1872-1887.
(33) Xiong Z, Jiang B, Wu PF, Tian J, Shi LL, Gu J, Hu ZL, Fu H, Wang F, Chen JG. Antidepressant effects of a plant-derived flavonoid baicalein involving extracellular signal-regulated kinases cascade. Biol Pharm Bull. 2011, 34(2):253-9.
近期代表性成果：
(1) Huang J, Fan H, Chen YM, Wang CN, Guan W, Li WY, Shi TS, Chen WJ, Zhu BL, Liu JF, Jiang B. The salt-inducible kinases inhibitor HG-9-91-01 exhibits antidepressant-like actions in mice exposed to chronic unpredictable mild stress. Neuropharmacology. 2023, 227:109437.
(2) Wang Y, Liu L, Gu JH, Wang CN, Guan W, Liu Y, Tang WQ, Ji CH, Chen YM, Huang J, Li WY, Shi TS, Chen WJ, Zhu BL, Jiang B. Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis. Mol Psychiatry. 2022 Nov 25, [Online ahead of print], doi: 10.1038/s41380-022-01881-4.
(3) Guan W, Xu DW, Ji CH, Wang CN, Liu Y, Tang WQ, Gu JH, Chen YM, Huang J, Liu JF, Jiang B. Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF. Pharmacol Res. 2021, 174:105932.
(4) Jiang B, Wang H, Wang JL, Wang YJ, Zhu Q, Wang CN, Song L, Gao TT, Wang Y, Meng GL, Wu F, Ling Y, Zhang W, Li JX. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway. Biol Psychiatry. 2019, 85(8):650-666.
(5) Song L, Wang H, Wang YJ, Wang JL, Zhu Q, Wu F, Zhang W, Jiang B. Hippocampal PPARα is a novel therapeutic target for depression and mediates the antidepressant actions of fluoxetine in mice. Br J Pharmacol. 2018, 175(14):2968- 2987.