刘兆国

师资介绍

刘兆国，男，汉，1987年11月生，博士，副教授，硕士研究生导师

研究方向：

消化系统疾病（结肠癌、肝纤维化）的发病机理与中药复方及活性成分干预研究

主持科研项目：

（1）国家自然科学基金委员会，面上项目，82374228，乌梅丸通过AHCY蛋白介导RIG-I乳酸化修饰调控巨噬细胞极化抗CAC的作用及机制研究，2024/01-2027/12，49万元，在研，主持

（2）国家自然科学基金委员会，青年基金，81703884，基于PKCδ介导的自噬调控探究黄葵胶囊对顺铂肾毒性的保护作用及分子机制，2018/01-2020/12，20万元，已结题，主持

（3）中国博士后科学基金会，面上项目，2018M642296，黄葵胶囊抗顺铂所致肾毒性的机理研究，2018/11-2020/08，5万元，已结题，主持

（4）江苏省教育厅，高等学校(自然科学)研究面上项目，17KJB360012，黄葵胶囊对顺铂肾毒性的保护作用及机理研究，2017/09-2019/08，3万元，已结题，主持

（5）南通市科技局，科技计划项目，JC2021025，基于 MIF/MIOX/铁死亡信号调控探究黄葵胶囊抗顺铂急性肾损伤的机制研究，2021/07-2023/06，5万元，已结题，主持

代表性论文：

（1）Zirong Deng^#, Yun Xu^#, Yuchen Cai, Weiling Lin, Libei Zhang, Aoqing Jiang, Yuhang Zhou, Rui Zhao, Heyan Zhao, Zhaoguo Liu^*（通讯作者） and Tingdong Yan^*. Inhibition of ribosomal RNA Processing 15 homolog (RRP15) suppressed tumor growth, invasion and epithelial to mesen-chymal transition (EMT) of colon cancer [J]. International Journal of Molecular Sciences, 2023, 24(4): 3528.

（2）Libei Zhang^#, Weiling Lin^#,Yunqing Cai^#, Ziyou Huang, Rui Zhao, Tingdong Yan, HongtaoXu^*, Zhaoguo Liu^*（通讯作者）. Farnesoid X receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of Alisol B 23-acetate in carbon tetrachloride-induced liver fibrosis in mice [J]. International Immunopharmacology, 2023, 123:110768.

（3）Jue Wang^#, Kang Ding^#, Yuhang Wang^#, Tingdong Yan, Yun Xu, Zirong Deng, Weiling Lin, Libei Zhang, Weizhong Zhu, Rui Zhao, Yuhang Zhou, Zhaoguo Liu^*（通讯作者）. Wumei Pill ameliorates AOM/DSS-induced colitis-associated colon cancer through inhibition of inflammation and oxidative stress by regulating S-adenosylhomocysteine hydrolase- (AHCY-) mediated hedgehog signaling in mice [J]. Oxidative Medicine and Cellular Longevity, 2022, 2022:4061713.

（4）Zhaoguo Liu^#（第一作者）, Mengjue Tu^#, Jiannan Shi^#, Hong Zhou, Guoliang Meng, Jianguo Gu^*, Yuqin Wang^*. Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects [J]. Frontiers in Pharmacology, 2022, 13:939317.

（5）Chang Chen^#, Jingya Gu^#, Jue Wang^#, Yu Wu, Aihua yang, Tingting Chen, Tingting Zhou, Zhaoguo Liu^*（通讯作者）. Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis throughinflammation inhibition by regulating SIRT3-mediated NF-κB P65nuclear expression [J] International Immunopharmacology, 2021, 90: 107206.

（6）Yuqin Wang^#, Chunling Li^#, Jingya Gu ^#, Chang Chen, Jiaxin Duanmu, Jing Miao, Wenjuan Yao, Jinhua Tao, Mengjue Tu, Biao Xiong, Lingling Zhao^*, Zhaoguo Liu^*（通讯作者）. Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signaling [J]. Journal of Cellular and Molecular Medicine, 2020, 24(1): 941-953.

（7）Jingya Gu^#, Chang Chen^#, Jue Wang#, Tingting Chen, Wenjuan Yao, Tingdong Yan^*, Zhaoguo Liu^*（通讯作者）. Withaferin A exerts preventive effect on liver fibrosis through oxidative stress inhibition in a sirtuin 3-dependent manner [J]. Oxidative Medicine and Cellular Longevity, 2020, 2020: 2452848.

（8）Jinlin Zhang, Aihua Yang, Yu Wu, Wei Guan, Biao Xiong, Xiaoqing Peng, Xiaojin Wei, Chang Chen, Zhaoguo Liu^*（通讯作者）. Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats [J]. Biomedicine & Pharmacotherapy, 2018, 97:1586-1594.

（9）Zhaoguo Liu^#,*（通讯作者）, Pingting Zhu^#, Lin Zhang, Biao Xiong, Jinhua Tao, Wei Guan, Chunling Li, Chang Chen, Jingya Gu, Jiaxin Duanmu, Wei Zhang ^*. Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis [J]. Biomedicine & Pharmacotherapy, 2018, 103:1262-1271.

（10）Lin Zhang^#, Chang Chen^#, Jiaxin Duanmu, Yan Wu, Jinhua Tao, Aihua Yang, Xiaoqin Yin, Biao Xiong, Jingya Gu, Chunling Li, Zhaoguo Liu ^*（通讯作者）. Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1α nuclear translocation [J]. International Immunopharmacology, 2018, 65: 429-437.

（11）Pingting Zhu^#, Yu Wu^#, Aihua Yang, Xingsheng Fu, Ming Mao, Zhaoguo Liu^*（通讯作者）. Catalpol suppressed proliferation, growth and invasion of CT26 colon cancer by inhibiting inflammation and tumor angiogenesis [J]. Biomedicine & Pharmacotherapy, 2017, 95:68-76.

（12）Zhaoguo Liu^#（第一作者）, Hongyan Wu^#, Zhonghong Wei, Xu Wang, Peiliang Shen, Siliang Wang, Aiyun Wang, Wenxing Chen, Yin Lu^*. TRPM8: a potential target for cancer treatment [J]. J Cancer Res Clin Oncol, 2016, 142(9):1871-1881.

社会学术兼职：

江苏省药理学会临床前药理专委会委员

江苏省双创人才（科技副总）

Frontiers in Bioscience-Landmark杂志编委

所获奖项及荣誉：

南通市首届十佳中药年度人物（2022）

南通大学第十二届青年教师讲课竞赛一等奖（2021）

南通大学优秀教育工作者（2021）

参编著作：

《血管生成研究方法与技术》（专著），人民卫生出版社，编委。

授权发明专利：

刘兆国，杨圣菊，彭晓露，陈畅，顾静雅. 白桦醇及其衍生物在制备抗肿瘤药物中的应用，专利号：ZL201910201989.5