姚文娟
师资介绍
姚文娟，女，汉，1983年4月生，教授，博士，基础药理系副主任
研究方向：
动脉粥样硬化、血管重构作用机制及防治研究
基金项目：
1.国家自然科学基金面上项目，81970226、SUMO化修饰调节RhoGDI蛋白降解在Ang介导的VSMC表型转化和动脉血管重构中的作用及机制研究、2020/01-2023/12、55万元、在研、主持；
2.江苏省高校自然科学研究重大项目，19KJA320010、RhoGDI 降解在平滑肌细胞转分化及血管重构中的作用及机制、2019/09-2022/08、15万元、在研、主持；
3.南通市科技计划项目，JC2018059、Rho 通路对波形蛋白的调控在内皮细胞凋亡中的作用及机制研究、2018/07-2020/06，3万元、在研、主持；
4.国家自然科学基金面上项目，81670243、蛋白磷酸酶1调控CaMKⅡδ可变剪接在心肌缺血再灌注损伤中的作用及机制研究、2017/01-2020/12、57万元、在研、参加；
5.国家自然科学基金面上项目，31670807、整合素蛋白N-糖链介导的膜功能复合物对 癌细胞增殖和浸润的调控及其作用机制的研究、2017/01-2020/12、65万元、在研、参加。
6.江苏省高校自然科学基金面上项目，16KJB360007、Rho/ROCK调控波形蛋白骨架及二苯乙烯苷的干预、2016/09-2018/08、3万元、结题、主持；
7.江苏省博士后科研资助计划，1601107C、Rho/ROCK在动脉粥样硬化发展中的作用及机制研究、2016/01-2017/12、3万元、结题、主持；
8.南通市科技计划项目，MS12015048、Rho/ROCK信号通路调控Vimentin骨架重排的分子机制及何首乌二苯乙烯苷干预作用研究、2015/10-2017/09，3万元、结题、主持；
9. 国家自然科学青年基金，81202879、何首乌活性成分二苯乙烯苷对波形蛋白骨架系统的调控及在防治动脉粥样硬化中的作用、2013/01-2015/12、23万元、结题、主持。
科研成果：
一、期刊论文
1. Qi Y, Guan H, Liang X, Sun J, Yao W （通讯作者）. Ang II Promotes SUMO2/3 Modification of RhoGDI1 Through Aos1 and Uba2 Subunits, and then Regulates RhoGDI1 Stability and Cell Proliferation. Cardiovasc. Drugs. Ther. 2021, 35(4): 769-773. (IF=3.727 , 二区)
2. Qi Y, Liang X, Guan H, Sun J, Yao W. RhoGDI1-Cdc42 Signaling Is Required for PDGF-BB-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Neointima Formation. Biomedicines. 2021, 9(9):1169. (IF=6.081, 二区)
3. Yan Qi, Xiuying Liang, Fan Dai, Haijing Guan, Jingwen Sun, Wenjuan Yao（通讯作者）. RhoA/ROCK pathway activation is regulated by AT1 receptor and participates in smooth muscle migration and dedifferentiation via promoting actin cytoskeleton polymerization. Int. J. Mol. Sci., 2020, 21 (15): 5398. (IF=4.556, 二区)
4. Xiuying Liang, Yan Qi, Fan Dai, Jingya Gu, Wenjuan Yao（通讯作者）. PVAT: an important guardian of the cardiovascular system. Histol. Histopathol., 2020, 35 (8): 779-787. (IF=2.021，四区)
5. Yan Qi, Xiuying Liang, Xia Hu, Haiyan He, Lian Tang, Wenjuan Yao（通讯作者）. Tetrahydroxystilbene glucoside protects against LPS-induced endothelial dysfunction via inhibiting RhoA/ROCK signaling and F-actin remodeling. Gen. Physiol. Biophys., 2020, 39 (5): 407-417. (IF=1.07，四区)
6. Fan Dai, Yan Qi, Wei Guan, Guoliang Meng, Zhaoguo Liu, Ting Zhang, Wenjuan Yao（通讯作者）. RhoGDI stability is regulated by SUMOylation and ubiquitination via the AT1 receptor and participates in Ang II-induced smooth muscle proliferation and vascular remodeling. Atherosclerosis 288 (2019) 124–136. (IF=4.255, 二区)
7. Lian Tang , Fan Dai, Yan Liu, Xiaoqiang Yu, Chao Huang, Yuqin Wang, Wenjuan Yao（通讯作者）. RhoA/ROCK signaling regulates smooth muscle phenotypic modulation and vascular remodeling via the JNK pathway and vimentin cytoskeleton. Pharmacological Research, 2018, 133: 201–212. (IF=7.658, 二区)
7. Lei Huang，Fan Dai，Lian Tang，Xiaofeng Bao，Zhaoguo Liu，Chao Huang，Ting Zhang，Wenjuan Yao（通讯作者）. Distinct Roles For ROCK1 and ROCK2 in the Regulation of Oxldl-Mediated Endothelial Dysfunction. Cell Physiol Biochem 2018;49:565-577. (IF=5.5, 二区)
9. Lifeng Yang, Lian Tang, Fan Dai, Guoliang Meng, Runting Yin, Xiaole Xu, Wenjuan Yao（通讯作者）. Raf-1/CK2 and RhoA/ROCK signaling promote TNF-α-mediated endothelial apoptosis via regulating vimentin cytoskeleton. Toxicology, 2017, 389: 74–84.（IF=4.099，二区）
10. Wenjuan Yao (第一作者兼通讯作者)，Chao Huang，Qinju Sun，Xiang Jing，Huiming Wang，Wei Zhang. Tetrahydroxystilbene glucoside protects against oxidized LDL-induced endothelial dysfunction via regulating vimentin cytoskeleton and its colocalization with ICAM-1 and VCAM-1. Cellular Physiology and Biochemistry, 2014, 34 (5): 1442-1454.（IF=5.5，二区）
11. Wenjuan Yao（第一作者兼通讯作者）, Huang Lei, Qinju Sun, Lifeng Yang, Lian Tang, Guoliang Meng, Xiaole Xu, Wei Zhang. The inhibition of macrophage foam cell formation by tetrahydroxystilbene glucoside is driven by suppressing vimentin cytoskeleton. Biomedicine & Pharmacotherapy, 2016, 83: 1132-1140.（IF=4.545，二区）
12. Yao WenJuan（第一作者），Fan WenJun，Huang Chao，Zhong Hui，Chen XiangFan, Zhang Wei. Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats. Biomedicine & Pharmacotherapy, 2013, 67 (2): 140-145. （IF= 4.545，二区）
13. Wenjuan Yao（第一作者兼通讯作者）, Chengjing Gu, Haoran Shao, Guoliang Meng, Huiming Wang, Xiang Jing, Wei Zhang. Tetrahydroxy stilbene glucoside improves TNF-α-induced endothelial dysfunction: involvement of TGFβ/Smad pathway, and inhibition of vimentin expression. The American Journal of Chinese Medicine, 2015, 43 (1): 183-198.（IF=3.12，三区）
14. Wenjuan Yao（第一作者兼共同通讯作者）, Qinju Sun, Lei Huang, Guoliang Meng, Huiming Wang, Xiang Jing, Wei Zhang. Tetrahydroxystilbene glucoside inhibits TNF-α-induced migration of vascular smooth muscle cells via suppression of vimentin. Canadian Journal of Physiology and Pharmacology, 2016, 94: 155-160. (IF=2.21, 四区)
15. Lifeng Yang, Fan Dai, Lian Tang, Yulan Le, Wenjuan Yao（通讯作者）. Macrophage differentiation induced by PMA is mediated by activation of RhoA/ROCK signaling. The Journal of Toxicological Sciences, 2017, 42(6): 763-771. (IF=1.737, 四区)
16. Jingjing Zhang, Lian Tang, Fan Dai, Yan Qi, Lifeng Yang, Zhaoguo Liu, Li Deng, Wenjuan Yao (通讯作者). ROCK inhibitors alleviate myofibroblast transdifferentiation and vascular remodeling via decreasing TGFβ1-mediated RhoGDI expression. Gen. Physiol. Biophys. (2019), 38, 271–280. (IF=1.309, 四区)
17. Yan Qi, Fan Dai, Jingya Gu, Wenjuan Yao. Biomarkers in VSMC phenotypic modulation and vascular remodeling. Pharmazie, 2019, 74 (12): 711-714. (IF=1.198, 四区)
二、其他成果
姚文娟，孟国梁，张伟，陈向凡，殷润婷，生产聚谷氨酸的重组谷氨酸棒杆菌及构建方法和用途，中国，ZL201310079151.6。
张伟; 姚文娟; 许晓乐; 王玉琴; 陈向凡, 复方黄精口服液及其制备方法, 2011. 07.19, 中国, ZL201110201940.3
三、获得学术奖励
张伟，许晓乐，姚文娟，王玉琴，黄燕娟，陈向凡，二苯乙烯苷稳定AS斑块的分子机制研究，南通市人民政府，南通市科学技术进步奖，二等奖，2010。
孟国梁，许晓乐，姚文娟，王玉琴，朱卫忠，张伟，药物靶向蛋白防治心血管疾病分子机制研究，江苏省药理学会，江苏药理科学技术奖，三等奖，2017。