黄超

师资介绍

黄超，男，汉族，1981.11，博士，教授，博士生导师

研究方向：

神经精神药理学，神经免疫药理学

社会学术兼职：

中国老年学和老年医学学会抗衰老分会委员；江苏省药理学会青年工作委员会副主任委员；江苏省药理学会抗炎免疫专委会副主任委员；江苏省免疫学会免疫与代谢专业委员会委员；江苏省免疫学会神经免疫专业委员会委员；中国药理学会神经精神药理专业委员会委员。

基金项目：

1. 国家自然科学基金面上项目，81974216，Nedd4-1介导内侧前额皮层CRTC1降解在抑郁症发生中的作用及机制研究，2020/01-2023/12，55万元，在研，主持

2. 国家自然科学基金面上项目，81771467，E3泛素连接酶Skp2通过促海马PPARα降解参与抑郁症发生的机制研究，2018/01-2021/12，54万元，在研，主持

3. 国家自然科学基金面上项目，81571323，法尼醇受体（FXR）通过CREB信号参与抑郁症病理生理过程的作用及机制研究，2016/01-2019/12，57万元，已结题，主持

4. 国家自然科学基金青年项目，81102428，干预星形胶质细胞TRPV1自噬性降解：缺血性脑损伤的治疗新策略，2012/01-2012/12，14万元，已结题，主持

5. 江苏省自然科学基金面上项目，BK20141240，二苯乙烯苷对星形胶质细胞谷氨酸转运体GLT1的调控及在脑缺血防治中的意义，2014/07-2017/06，10万元，在研，主持

6. 江苏省六大人才高峰计划项目，SWYY-071，核受体NR6A1通过CREB信号参与抑郁症发生的机制研究，2018/07-2021/06，4万元，在研，主持

7. 南通市科技计划项目，MS12018078，两性霉素B脂质体通过ATP-P2Y1受体-谷氨酸能神经传递信号发挥抗抑郁作用的机制，2018/07-2020/06，10万元，在研，主持

8. 南通市科技计划项目，MS12015050，以新型法尼基水杨酸衍生物为基础的抗类风湿性关节炎药物筛选与机制研究，2015/10-2018/09，3万元，结题，主持

9. 校企合作横向科研攻关课题，20ZH443，益生菌对情绪障碍疾病的缓解作用研究，2020/08-2022/07，10万元，在研，主持

10. 国家自然科学基金面上项目，81171258，NO调控伏隔核脑区突触可塑性在苯丙胺成瘾戒断中的作用及其机制，2012/01-2015/12，55万元，已结题，参加

11. 国家自然科学基金面上项目，81173071，酸敏感离子通道（ASICs）：小胶质细胞炎症免疫反应的重要调节蛋白，2012/01-2015/12，60万元，已结题，参加

12. 国家自然科学基金青年项目，30901804，心肌酸敏感离子通道（ASICs）：治疗心肌缺血的新靶点，2010/01-2012/12，23万元，已结题，参加

13. 国家自然科学基金青年项目，30800331，PICK1在ASICs参与的炎性疼痛中所起的作用及其具体机制，2009/01-2011/12，20万元，已结题，参加

科研成果：

近5年侧重于抑郁症、焦虑症、创伤后应激障碍等情绪障碍疾病研究。课题组主要应用分子生物学、组织与细胞形态学、神经化学与药理学、基因干预与行为学等多学科交叉策略研究核受体、脑源性生长因子信号及外周/中枢免疫炎症反应与抑郁症、焦虑症、创伤后应激障碍等情绪障碍疾病的关系，着力探讨预防和治疗情绪障碍疾病的潜在药物和特异性生物学靶标。

近5年工作受到国家自然科学基金委员会、江苏省科技厅和南通市科技局各类基金项目支持，包括1项国家自然科学基金青年科学基金、3项国家自然科学基金面上项目、1项江苏省六大人才高峰计划项目、1项江苏省自然科学基金面上项目、2项南通市科技计划项目支持，参与抑郁症相关973课题研究，取得了一系列具有显著科学价值和创新意义的成果，其中有关小胶质细胞功能/形态可塑性调控及大脑CREB信号功能失调与抑郁症关系的研究为推动抑郁症神经炎症假说和营养因子失衡假说的发展，及以此为基础的抑郁症新型病理生理学机制和治疗药物的研究奠定了扎实的基础。

在Brain Behavior Immun、Glia、Neurobiol Dis、Neuropharmacology、Pharmacol Res、Int J Neuropsychopharmacol、Prog Neuropsychopharmacol Biol Psychiatry、Psychopharmacology (Berl)、J Neuroinflammation、British J Pharmacology、FEBS Lett、Neuroscience等期刊发表专业学术论文50余篇，其中中科院JCR分区1区论文5篇，2区论文13篇，论文累积被引800余次。

成果奖励：

1、江苏省药理科学技术进步奖，靶向小胶质细胞的抑郁症发病机制及治疗策略研究，二等奖

2、江苏省高等学校科学技术研究成果奖，靶向小胶质细胞的抑郁症发病机制及防治策略研究，三等奖

3、南通大学优秀教育工作者

4、南通大学优秀党员

代表性论文：

1. Gu Y^#, Ye T^#, Tan P^#, Tong L^#, Ji J, Gu Y, Shen Z, Shen X, Lu X*, Huang C*. Tolerance-inducing effect and properties of innate immune stimulation on chronic stress-induced behavioral abnormalities in mice. Brain Behav Immun. 2021, 91:451-471. (IF: 7.217)

2. Huang C^#, Wang P^#, Xu X^#, Zhang Y, Gong Y, Hu W, Gao M, Wu Y, Ling Y, Zhao X, Qin Y, Yang R*, Zhang W*. The ketone body metabolite β-hydroxybutyrate induces an antidepression-associated ramification of microglia via HDACs inhibition-triggered Akt-small RhoGTPase activation. Glia. 2018, 66(2):256–278. (IF: 7.452)

3. Huang C^#, Hu ZL^#, Wu WN, Yu DF, Xiong QJ, Song JR, Shu Q, Fu H, Wang F, Chen JG*, Existence and distinction of acid-evoked currents in rat astrocytes, Glia, 2010, 58(12): 1415–1424. (IF: 7.452)

4. Huang C^#, Lu X^#, Tong LJ, Wang JL, Zhang W, Jiang B, Yang RR^*, Requirement for endogenous heat shock factor 1 in inducible nitric oxide synthase induction in murine microglia,J Neuroinflammation, 2015, 12(1): 189. (IF: 8.322)

5. Huang C^#, Wang YZ^#, Wang J, Yao WJ, Chen XF, Zhang W^*, TSG (2,3,4’,5-tetrahydroxystilbene 2-O-β-D-glucoside) suppresses induction of pro-inflammatory factors by attenuating the binding activity of nuclear factor-κB in microglia, J Neuroinflammation, 2013, 10(29): 129.(IF: 8.322)

6. Yang R^#, Wang H^#, Wen J, Ma K, Chen D, Chen Z, Huang C^*. Regulation of microglial process elongation, a featured characteristic of microglial plasticity. Pharmacol Res. 2019, 139:286–297.(IF: 7.658)

7. Xu X^#, Hu P^#, Ma Y^#, Tong L, Wang D, Wu Y, Chen Z, Huang C^*. Identification of a pro-elongation effect of diallyl disulfide, a major organosulfur compound in garlic oil, on microglial process. J Nutr Biochem. 2020, 78:108323. (IF: 6.408)

8. Wu Y^#, Gao M^#, Wu J^#, Hu P, Xu X, Zhang Y, Wang D, Chen Z, Huang C^*. Sulforaphane triggers a functional elongation of microglial process via the Akt signal. J Nutr Biochem. 2019, 67:51–62. (IF: 6.408)

9. Wang P ^#, Zhang YR^#, Gong Yu^#, Yang RR, Chen Z, Hu WF, Wu Y, Gao MH, Xu X, Qin YB, Huang C*. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition.Neurobiol Dis. 2018, 111:12–25. (IF: 5.996)

10. Hu W^#, Wu J^#, Ye T^#, Chen Z, Tao J, Tong L, Ma K, Wen J, Wang H, Huang C*. Farnesoid X receptor-mediated cytoplasmic translocation of CRTC2 disrupts CREB-BDNF signaling in hippocampal CA1 and leads to the development of depression-like behaviors in mice. Int J Neuropsychopharmacol. 2020, 26:pyaa039. (IF: 5.176)

11. Ye T^#, Wang D^#, Cai Z^#, Tong L, Chen Z, Lu J, Lu X, Huang C*, Yuan X*. Antidepressive properties of macrophage-colony stimulating factor in a mouse model of depression induced by chronic unpredictable stress. Neuropharmacology. 2020, 172:108132. (IF: 5.25)

12. Hu P^#, Wang D^#, Zhang Y^#, Cai Z, Ye T, Tong L, Xu X, Lu J, Liu F, Lu X, Huang C*. Apoptosis-triggered decline in hippocampal microglia mediates adolescent intermittent alcohol exposure-induced depression-like behaviors in mice. Neuropharmacology. 2020, 170:108054. (IF: 5.25)

13. Cai Z^#, Ye T^#, Xu X^#, Gao M, Zhang Y, Wang D, Gu Y, Zhu H, Tong L, Lu J, Chen Z, Huang C*. Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress. Prog Neuropsychopharmacol Biol Psychiatry. 2020, 101:109931. (IF: 4.361)

14. Gao M^#, Hu P^#, Cai Z^#, Wu Y, Wang D, Hu W, Xu X, Zhang Y, Lu X, Chen D, Chen Z, Ma K, Wen J, Wang H, Huang C*. Identification of a microglial activation-dependent antidepressant effect of amphotericin B liposome. Neuropharmacology. 2019, 151:33–44. (IF: 5.25)

15. Wang D^#, Xu X^#, Wu Y, Lin Y, Gao M, Hu P, Chen D, Lu X, Chen Z, Wang H, Huang C*. SMIP004: A compound with antidepressant-like activities in mouse models. Eur J Pharmacol. 2019, 843:260–267. (IF: 4.432)

16. Gong Y^#, Tong L^#, Yang R, Hu W, Xu X, Wang W, Wang P, Lu X, Gao M, Wu Y, Xu X, Zhang Y, Chen Z, Huang C*. Dynamic changes in hippocampal microglia contribute to depressive-like behavior induced by early social isolation.Neuropharmacology. 2018, 135:223–233.(IF: 5.25)

17. Liu FG^#, Wu JJ^#, Gong Y, Wang P, Lei Z, Tong LJ, Chen XF, Ling Y, Huang C*. Harmine produces antidepressant-like effects via restoration of astrocytic functions.Prog Neuropsychopharmacol Biol Psychiatry. 2017, 79:258–267.(IF: 5.067)

18. Wu J, Hu W, Gong Y, Wang P, Tong L, Chen X, Chen Z, Xu X, Yao W, Zhang W, Huang C. Current pharmacological developments in 2,3,4',5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG).Eur J Pharmacol. 2017, 811:21–29.(IF: 4.432)

19. Tong JL^#, Gong Y^#, Wang P, Hu WF, Wang JL, Chen Z, Zhang W, Huang C^*. Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses.Neurochem Res. 2017, 42:2698–2711.(IF: 3.996)

20. YangRR, Wang P, Chen Z, Hu WF, Gong Y, Zhang W, Huang C^*. WY-14643, a selective agonist of peroxisome proliferator-activated receptor-α, ameliorates lipopolysaccharide-induced depressive-like behaviors by preventing neuroinflammation and oxido-nitrosative stress in mice.Pharmacol Biochem Behav. 2017, 153:97–104.(IF: 3.533)

21. Liu FG^#, Hu WF^#, Wang JL, Wang P, Gong Y, Tong LJ, Jiang B, Zhang W, Qin YB, Chen Z, Yang RR, Huang C^*. Z-guggulsterone Produces Antidepressant-like Effects in Mice Through Activation of the BDNF Signaling Pathway.Int J Neuropsychopharmacol. 2017, 20:485–497. (IF: 5.176)

22. Huang C^#, Lu X^#, Wang JL^#, Tong JL, Ling Y, Jiang B, Yang RR^*, Zhang W^*, Compound C induces the ramification of murine microglia in an AMPK-independent and small rhogtpase-dependent manner,Neuroscience, 2016, 331: 24–39.(IF: 3.59)

23. Huang C^#, Wang JL^#, Hu WF^#, Wang CN, Lu X, Tong LJ, Wu F, Zhang W^*, Identification of functional farnesoid X receptors in brain neurons,FEBS Lett, 2016, 590(18):3233–3242.(IF: 4.124)

24. Zhang J, Wu J, Liu F, Tong L, Chen Z, Chen J, He H, Xu R, Ma Y, Huang C*. Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review. Eur J Pharmacol. 2019, 858:172500. (IF: 4.432)

25. Huang C, Wu J, Chen D, Jin J, Wu Y, Chen Z. Effects of sulforaphane in the central nervous system. Eur J Pharmacol. 2019, 853:153-168. (IF: 4.432)

26. Huang C^#, Wu JJ^#, Xu L, Wang JL, Chen Z, Yang RR*. Regulation of HSF1 protein stabilization: An updated review.Eur J Pharmacol. 2018, 822:69–77.(IF: 4.432)

27. Huang C^#, Wang JL^#, Lu X, Hu WF, Wu F, Jiang B, Ling Y, Yang RR^*, Wei Zhang^*, Z-guggulsterone Negatively Controls Microglia-Mediated Neuroinflammation Via Blocking IκB-α-NF-κB Signals,Neurosci Lett, 2016, 916:34–42.(IF: 3.046)

28. Huang C^#,Lu X^#, Wang J^#, Tong LJ, Jiang B, Zhang W^*, Inhibition of endogenous heat shock protein 70 attenuates inducible nitric oxide synthase induction via disruption of heat shock protein 70/Na⁺/H⁺ exchanger 1-Ca²⁺-calcium-calmodulin-dependent protein kinase II/transforming growth factor β-activated kinase 1-nuclear factor-κB signals in BV-2 microglia,J Neurosci Res, 2015, 93(8): 1192–1202. (IF: 4.164)