陈广通
师资介绍
陈广通,男,汉族,1981.02,教授,博士
研究方向：
中药和天然药物药效物质基础及活性成分生物转化研究
基金项目：
1)、主持国家自然科学基金项目“达玛烷型三萜类成分生物转化及构效关系的研究”，研究起止时间为2012—2014年，项目编号：81102327。
2)、主持江苏省高校自然科学研究面上项目“原人参二醇的微生物转化及抗肿瘤作用研究”，研究起止时间为2010—2012年，项目编号：10KJB350003。
3)、主持南通市自然科学研究项目“牡荆子抗哮喘药效物质基础及体内药代动力学研究”，研究起止时间为2011—2013年，项目编号：AS2011019。
4)、主持南通市自然科学研究项目“达玛烷型三萜的生物转化及抗肝纤维化构效关系研究”，研究起止时间为2015—2017年，项目编号：MS12015044。
5）、主持南通市自然科学研究项目“基于TGF-β1/Smad和MAPK信号通路的羽扇豆烷型三萜及其治疗肾脏纤维作用研究”，研究起止时间为2018—2020年，项目编号：JC2018122。
6)、主持南通市自然科学研究重点项目“新冠病毒肺炎恢复期肺脾气虚证治疗处方中三萜类有效组分的发现及其作用机制研究”，研究起止时间为2012—2024年，项目编号：MS12022026。
获奖情况：
1.2016年度南通市科学技术进步奖三等奖（第一完成人）
2.2016年选派为江苏省“企业创新岗”特聘专家（科技副总）；
3.2015年获南通大学2014年度优秀教学质量管理奖荣誉称号；
4.2014年获南通大学2013年度优秀教学质量奖荣誉称号；
5.2013年入选江苏省第四期“333高层次人才培养工程”第三层次培养对象；
6.2013年获南通大学优秀教育工作者荣誉称号；
7.2010年获江苏省普通高等学校本专科优秀毕业设计（论文）评选三等奖（指导教师）；获南通大学优秀毕业设计（论文）一等奖2次（2010届和2012届，指导教师）；获南通大学毕业设计（论文）优秀指导教师3次（2009年、2010年和2012年）
代表性论文：
1. Lu, Youjia; Tang, Yifei; Wu, Yanni; Zhang, Xueying; Yi, Ying; Wang, Wenli; Wang, Andong; Yang, Min; Fan, Boyi; Chen, Guangtong. Microbial transformation of betulonic acid by Circinella muscae CGMCC 3.2695 and anti-neuroinflammatory activity of the products. Phytochemistry 2022, 204: 113431.
2. Chu, CJ; Song, KN; Zhang, YZ ; Yang, M; Fan, BY; Huang, HL; Chen, GT. Biotransformation of ursolic acid by Circinella muscae and their anti-neuroinflammatory activities of metabolites. Natural Product Research 2022, 36(11): 2777-2782.
3. K-N Song, Y-J Lu, C-J Chu, Y-N Wu, H-L Huang, B-Y Fan, G-T Chen. Biotransformation of betulonic acid by the fungus Rhizopus arrhizus CGMCC 3.868 and antineuroinflammatory activity of the biotransformation products. Journal of natural products 2021, 84: 2664-2674.
4. C Chen, K-N Song, Y-Z Zhang, C-J Chu, B-Y Fan, Y Song (*), H-L Huang, G-T Chen (*). Biotransformation of betulinic acid by Circinella muscae and Cunninghamella echinulata to discover anti-inflammatory derivatives. Phytochemistry 2021, 182: 112608.
5. C Chen, Y-H Ni, B-C Jiang, B-H Xu, B-Y Fan, H-L Huang, G-T Chen. Anti-aging derivatives of cycloastragenol produced by biotransformation. Natural Product Research 2021, 35(16): 2685-2690.
6. J-L Li, B-C Jiang, C Chen, B-Y Fan, H-L Huang, G-T Chen (*). Biotransformation of betulin by Mucor subtilissimus to discover anti-inflammatory derivatives. Phytochemistry 2019，166: 112076.
7. B-Y Fan, Y Lu, M Yang, J-L Li (*), G-T Chen (*). Evolvulins I and II, resin glycosides with a trihydroxy aglycone unit from Evolvulus alsinoides. Organic Letters 2019, 21(16): 6548-6551.
8. B-Y Fan, H Ye, Y Lu, M Yang, Q Zhu, G-T Chen (*), J-L-Li (*). Glycosidic acids with unusual aglycone units from Convolvulus arvensis. Journal of natural products 2019, 82(6): 1593-1598.
9. B-Y Fan, B-C Jiang, S-S Yan, B-H Xu, H-L Huang, G-T Chen (*). Anti-inflammatory 18β-glycyrrhetinin acid derivatives produced by biocatalysis. Planta Medica 2019, 85(1): 56-61.
10. S-S Yan, H-J Lin, H-L Huang, M Yang, B-H Xu, G-T Chen (*). Microbial hydroxylation and glycosidation of oleanolic acid by Circinella muscae and their anti-inflammatory activities. Natural Product Research 2019, 33(13): 1849-1855.
11. J-L Li, P-Y Ding, B-C Jiang, M Yang, J Ren, Y Song, G-T Chen (*). Biotransformation of 20(R)-panaxatriol by the fungus Aspergillus flavus Link AS 3.3950. Natural Product Research 2019, 33(10): 1393-1398.
12. H-J Lin, B-C Jiang, C Chen, Y Song, M Yang, H-L Huang, G-T Chen (*). Microbial transformation of the anti-aging agent cycloastragenol by Mucor racemosus. Natural Product Research 2019, 33(21): 3103-3108.
13. B-Y Fan, Y Lu, H Yin, Y He, J-L Li (*), G-T Chen (*). Arvensic acids A-D, novel heptasaccharide glycosidic acids as the alkaline hydrolysis products of crude resin glycosides from Convolvulus arvensis. Fitoterapia 2018, 131: 209-214.
14. Y-Q Gu, P-Y Ding, Z-P Liang, Y Song, Y-H Liu, G-T Chen (*), J-L Li (*). Activated production of silent metabolites from marine-derived fungus Penicillium citrinum. Fitoterapia 2018, 127: 207-211.
15. B Yan, Z-H Chen, X-G Zhai, G-BYin, Y-F Ai, G-T Chen (*). Microbial carbonylation and hydroxylation of 20(R)-panaxadiol by Aspergillus niger. Natural Product Research 2018, 32(7): 782-787.
16. Y Song, S-S Yan, H-J Lin, J-L Li, X-G Zhai, J Ren, G-T Chen (*). Biotransformation of 20(R)-panaxadiol by whole cells of filamentous fungus Absidia coerulea AS 3.3382. Journal of Asian Natural Products Research 2018, 20(8): 719-726.
17. G-T Chen, Y Lu, M Yang, J-L Li, B-Y Fan. Medicinal uses, pharmacology, and phytochemistry of Convolvulacee plants with central nervous system efficacies: A systematic review. Phytotherapy Research 2018, 32(5): 823-864.
18. Y Song, J Li, S-S Yan, H-J Lin, J-L Li, J-J Wu, X-G Zhai, G-T Chen(*). Biotransformation of 20(R)-panaxatriol by Aspergillus niger AS 3.739. Phytochemistry Letters 2017, 19: 89-93.
19. G-T Chen, J Li, S-S Yan, H-J Lin, J-J Wu, X-G Zhai, Y Song, J-L Li. Biotransformation of 20(R)-panaxatriol by Mucor racemosus and the anti-hepatic fibrosis activity of some products. Natural Product Research 2017, 31(16): 1880-1885.
20. G-T Chen, M Yang, B-B Chen, Y Song, W Zhang, Y Zhang. 2,3,5,4'-Tetrahydroxystilbene-2-O-b-D-glucoside exertedprotective effects on diabetic nephropathy in mice with hyperglycemia induced by streptozotocin. Food & Function 2016, 7: 4628-4636.
21. G-T Chen, H-J Ge, J Li, J-L Li, X-G Zhai, J-J Wu, Y Song. Microbial transformation of 20(R)-panaxadiol by Absidia corymbifera AS 3.3387. Journal of Molecular Catalysis B: Enzymatic 2016, 123: 154-159.
22. G-T Chen, H-J Ge, Y Song, J-L Li, X-G Zhai, J-J Wu, X Ling. Biotransformation of 20(S)-protopanaxatriol by Mucor racemosus and the anti-cancer activities of some products. Biotechnology Letters 2015, 37: 2005-2009.
23. X Yang, H-J Ge, Y Song, J-L Li, G-T Chen(*). Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus. Biotechnology Letters 2015, 37: 397-402.
24. G-T Chen, Y Song, H-J Ge, J Ren, X Yang, J-L Li. Biotransformation of 20(S)-protopanaxatriol by Aspergillus niger and the cytotoxicity of the resulting metabolites. Phytochemistry Letters 2015, 11: 111-115.
25. J-L Li, L Huang, J Liu, Y Song, J Gao, J-H Jung, Y-H Liu(*), G-T Chen(*). Acetylcholinesterase inhibitory dimericindole derivatives from the marine actinomycetes Rubrobacter radiotolerans. Fitoterapia 2015, 102: 203-207.
26. G-T Chen, X Yang, J-L Li, H-J Ge, Y Song, J Ren. Biotransformation of 20(S)-protopanaxadiol by Aspergillus niger AS 3.1858. Fitoterapia 2013, 91: 256-260.
27. G-T Chen, M Yang, S-J Nong, X Yang, Y Ling, D-G Wang, X-Y Wang, W Zhang. Microbial transformation of 20(S)-protopanaxadiol by Absidia corymbifera. Cytotoxic activity of the metabolites against human prostate cancer cells. Fitoterapia 2013, 84: 6-10.
28. G-T Chen, X Yang, X-G Zhai, M Yang. Microbial transformation of 20(S)-protopanaxatriol by Absidia corymbifera and their cytotoxic activities against two human prostate cancer cell lines. Biotechnology Letters 2013, 35: 91-95.
29. G-T Chen, X Yang, S-J Nong, M Yang, B-H Xu, W Zhang. Two novel hydroperoxylated products of 20(S)-protopanaxadiol produced by Mucor racemosus and their cytotoxic activities against human prostate cancer cells. Biotechnology Letters 2013, 35: 439-443.